Fetus-In-Fetu

By Nisreen M Khalifa et al - Khalifa NM, Maximous DW, Abd-Elsayed AA. Fetus in fetu: a case report. J Med Case Reports. 2, 2. 2008. doi:10.1186/1752-1947-2-2. PMID 18186928., CC BY 2.0, https://commons.wikimedia.org/w/index.php?curid=4260020

Although there is nothing practical to learn, for daily living, from this interesting case of fetus-in-fetu, it is nevertheless interesting to read about.  Perhaps the study of such abnormalities can be useful for studies of cancer and other aberrations of developmental processes.  Abstract:

A case of fetus-in- fetu is reported. It occurred in an 8-week-old Korean boy who had been born by cesarean section due to abdominal distension. The fetus-in- fetu was connected to the superior mesenteric artery and consisted of two masses, apparently representing two portions of an acardiac monster. There was an amniotic membrane covering both masses, and the umbilical cord clearly was identifiable. One mass included the brain, eye, trachea, salivary glands, thyroid, pancreas, spleen, etc., while the other mass contained extremity bones, vertebrae, testis, adrenals, and intestinal loops. This is probably a case of separated fetus-in- fetu that showed unusually well-developed internal organs.

Chickens And Fetal Alcohol Syndrome

Mice are not the only animal model used to study human disorders. Avian embryos, in the case the chicken, can be used as model to investigate fetal alcohol syndrome, a devastating disorder that occurs wen pregnant women ignore the injunction against drinking alcohol.  These model organisms can be used to determine mechanisms by which alcohol does its damage, stressing cell signaling pathways, with the eventual hope of better dealing with the effects of this disorder.  Of course, the best therapy here, as with almost all disorders, is prevention.  Don't drink alcohol when pregnant.  Abstract:

Prenatal alcohol exposure (PAE) remains a leading preventable cause of structural birth defects and permanent neurodevelopmental disability. The chick (Gallus gallus domesticus) is a powerful embryological research model and was possibly the first (Fere, 1895) in which alcohol's teratogenicity was demonstrated. Pharmacologically relevant alcohol exposures in the range of 20-70 mM (20-80 mg/egg) disrupt chick embryo growth, morphogenesis, and behavior, and the resulting phenotypes strongly parallel those of mammalian models. The avian embryo's direct accessibility has enabled novel insights into alcohol's teratogenic mechanisms. These include the contribution of IGF1 signaling to growth suppression, the altered flow dynamics that reshape valvuloseptal morphogenesis and mediate its cardiac teratogenicity, and the suppression of Wnt and Shh signals to disrupt neural crest migration, expansion, and survival and underlie its characteristic craniofacial deficits. The genetic diversity within commercial avian strains enabled identification of unique loci, such as ribosome biogenesis, that modify vulnerability to alcohol. This venerable research model is equally relevant for the future, as the application of technological advances including CRISPR, optogenetics, and biophotonics to the embryo's ready accessibility creates a unique model in which investigators can manipulate and monitor the embryo in real-time to investigate alcohol's actions upon cell fate.