At left, colorectal cancer diagram, By Blausen Medical Communications, Inc. - Donated via OTRS, see ticket for details, CC BY 3.0, https://commons.wikimedia.org/w/index.php?curid=27639260
Certain bacterial species in the gut microbiota enhanced risk of colorectal cancer (CRC). Can diet influence the risk of developing CRC associated with those bacteria? The answer seems to be yes, as described in this paper. Excerpts from the abstract:
Importance: Fusobacterium nucleatum appears to play a role in colorectal carcinogenesis through suppression of the hosts' immune response to tumor. Evidence also suggests that diet influences intestinal F nucleatum. However, the role of F nucleatum in mediating the relationship between diet and the risk of colorectal cancer is unknown.
Objective: To test the hypothesis that the associations of prudent diets (rich in whole grains and dietary fiber) and Western diets (rich in red and processed meat, refined grains, and desserts) with colorectal cancer risk may differ according to the presence of F nucleatum in tumor tissue.
Conclusions and Relevance: Prudent diets rich in whole grains and dietary fiber are associated with a lower risk for F nucleatum - positive colorectal cancer but not F nucleatum - negative cancer, supporting a potential role for intestinal microbiota in mediating the association between diet and colorectal neoplasms.
In summary, diets high in whole grains and fiber reduce risk of CRC associated with F nucleatum, but not for CRC not associated with that species. This is evidence that the gut microbiota plays an important role in mediating the effects of diet on CRC, and further suggests the power of diet and gut microbiota management for cancer prevention. I’ll be eating my whole grains and fiber.
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