Wednesday, May 24, 2017

Genes For Intelligence Discovered

IQ distribution centered around a mean of 100 shown at left.  By Dmcq - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=29433851

Some genes associated with intelligence have been discovered. Abstract:

Intelligence is associated with important economic and health-related life outcomes. Despite intelligence having substantial heritability (0.54) and a confirmed polygenic nature, initial genetic studies were mostly underpowered. Here we report a meta-analysis for intelligence of 78,308 individuals. We identify 336 associated SNPs (METAL P < 5 × 10-8) in 18 genomic loci, of which 15 are new. Around half of the SNPs are located inside a gene, implicating 22 genes, of which 11 are new findings. Gene-based analyses identified an additional 30 genes (MAGMA P < 2.73 × 10-6), of which all but one had not been implicated previously. We show that the identified genes are predominantly expressed in brain tissue, and pathway analysis indicates the involvement of genes regulating cell development (MAGMA competitive P = 3.5 × 10-6). Despite the well-known difference in twin-based heratiblity for intelligence in childhood (0.45) and adulthood (0.80), we show substantial genetic correlation (rg = 0.89, LD score regression P = 5.4 × 10-29). These findings provide new insight into the genetic architecture of intelligence.

Not much you can do about this for your own life of course, other than making the most of what you have.  The mind needs to be exercised as much as the body, and as a middle-aged man I wish that the younger generation would do more reading of books and less social media.

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