Showing posts with label CRISPR. Show all posts
Showing posts with label CRISPR. Show all posts
Friday, September 21, 2018

More On CRISPR

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Using new methodologies to optimize the CRISPR system .  Abstract: CRISPR-Cas systems offer versatile technologies for genome engineer...
Wednesday, August 1, 2018

Multiplex Genome Editing

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It is now becoming possible to perform multiple editing of genomes , a "DNA construction site" toolkit, which can enable a num...
Saturday, June 30, 2018

CRISPR Editing In Blood Stem Cells

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CRISPR editing in blood stem cells ; abstract: Genome editing via homologous recombination (HR) (gene targeting) in human hematopoieti...
Monday, June 25, 2018

p53 Inhibits CRISPR-Cas9 Engineering In Human Pluripotent Stem Cells

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Human pluripotent stem cells are difficult to engineer with the CRSPR system compared to other cell types, which is unfortunate given the g...
Wednesday, May 23, 2018

Another CRISPR Modification

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Customizing cell circuits for gene expression control.  Abstract: The catalytically dead Cpf1 endonuclease from Acidaminococcus sp. BV...
Tuesday, May 1, 2018

Gene Therapy Delivery

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Public Domain, https://commons.wikimedia.org/w/index.php?curid=488192 By Nandiyanto - Own work, Public Domain, http...
Wednesday, April 25, 2018

Salmonella And Colon Cancer

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Public Domain, https://commons.wikimedia.org/w/index.php?curid=450281  Salmonella, at least in mouse models, can promote colon cancer...
Tuesday, April 17, 2018

"Big Papi" CRISPR Screening Approach

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The "Big Papi" (paired aureus and pyogenes for interactions) approach to CRISPR screening will uncover new genetic-to-phenotyp...
Sunday, February 4, 2018

Epigenetic CRISPR

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Epigenetics is the modulation of gene expression through modification of chromatin (e.g., by methylation and/or acetylation) without chan...
Sunday, January 28, 2018

CRISPR Targeting RNA

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The CRISPR system is a crucially important, relatively new, system for targeted modification of DNA, and one that has implications for gene...
Sunday, December 24, 2017

Gene Therapy For Deafness

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Here we see a CRISPR-based system for gene therapy against a form of hereditary deafness, tested fairly successfully in the Beethoven mou...
Wednesday, December 20, 2017

Looping DNA

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The formation of DNA loops is an integral mechanism in the control of gene expression, bringing various control regions of DNA, and their...
Wednesday, November 29, 2017

Gene Therapy Advance

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An important methodological advance that can be of use for gene therapy is described here .  This is a modification of the CRISPR system th...
Friday, November 3, 2017

CRISPR For HIV Treatment?

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This paper is an analysis of the future potential of the CRISP gene editing method as a therapeutic approach against HIV infection.  It ...