Showing posts with label signaling. Show all posts
Showing posts with label signaling. Show all posts
Monday, June 3, 2019

Low Oxygen And Osteogenic Differentiation

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Low oxygen conditions can affect the differentiation of bone precursor cells.  Abstract: This study examined the effects of low oxyg...
Tuesday, March 26, 2019

Wnt Signaling And Angiogenesis

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Blocking angiogenesis to prevent tumors from getting their blood supply is an important therapeutic approach; Wnt signaling is involved .  ...
Tuesday, February 26, 2019

Clock And Cycle: Wnt Signaling

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The circadian clock controls daily life activities; the cell cycle is what allows cells to proliferate.  The two are linked via cell sign...
Monday, January 7, 2019

Aging And Heart Failure Links

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The obvious aging-heart failure link has links to cell signaling; understanding these links can lead to novel therapies.  Abstract: Th...
Tuesday, December 18, 2018

Resistance to Cancer Immune Therapy: TNF Signaling

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Resistance to cancer immune therapy seems to involve downregulation of tumor necrosis factor (TNF) signaling, which possibly in the future ...

Anti-Epileptic Drugs And Bone Loss

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Drugs against epilepsy can cause bone loss , particularly in post-menopausal women.  A study in rats demonstrated that this is due to chang...
Tuesday, November 20, 2018

Rimonabant And Colorectal Cancer

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Targeted killing of neoplastic colon cells; abstract: Colorectal cancer (CRC), like other tumor types, is a highly heterogeneous disea...
Saturday, October 6, 2018

TGIF1 In Colorectal Cancer

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TGIF1 is another molecular factor discovered to promote colorectal cancer , apparently by upregulating the deregulated Wnt signaling found ...
Saturday, August 4, 2018

Dietary Influences On The Plasma Membrane: Cancer Implications

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Diet can affect the cell plasma membrane and hence decrease caner risk, through modulation of cell signaling. Abstract: The cell pl...
Tuesday, July 31, 2018

Natural Product Polyphenols Against Cancer

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Natural product polyphenols that can be obtained through diet can have anti-cancer properties , particularly with respect to cancer driven ...
Sunday, July 8, 2018

Real Time Dynamics Of β-Catenin Expression During Hydra Development, Regeneration And Wnt Signalling Activation.

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Understanding cell signaling in the immortal organism, the Hydra.  Abstract: Understanding the dynamic cellular behaviours driving m...
Monday, July 2, 2018

Extracellular Vesicles Carrying Messages For Bodily Adaptions To Physical Exercise

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The well-known adaptions to exercise is mediated by “cross-talk” between body tissues, and this “talk” seems to be itself mediated by certa...
Friday, June 29, 2018

Cytoplasmic DNA And Metastasis

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Chromosomal instability results in DNA in the cytoplasm, which is of course not normal, DNA being normally found only in the nucleus.  This...

Colon Cancer Mutations Associated With The Gut Microbiota

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An extremely important study on colon cancer concludes: “We found statistically significant associations between loss-of-function mutatio...
Thursday, June 21, 2018

Inhibiting Hippo For Heart Repair

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Altering cell signaling pathways, as discussed here with the Hippo pathway, holds promise to enhance the regenerative capacity of damaged t...
Wednesday, June 13, 2018

Against Colitis And Cancer

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Chronic inflammation of the colon can increase risk for cancer; an antibody to a pro-inflammatory mediator can reduce inflammation in a mou...
Friday, June 1, 2018

Sleeping Flies

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How is sleep controlled?  Selection for fruit flied with long or short time sleep periods demonstrates the importance of certain key sign...
Saturday, May 26, 2018

Notch And The Heart

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Notch signaling is required for proper heart function; abstract: Background -Nutrients are transported through endothelial cells before...
Tuesday, May 22, 2018

Limb Regeneration In Humans

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Higher animals such as humans lack the limb regeneration capacity of amphibians, for the reasons outlined in the abstract below. Revers...

Three Is Enough

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Colorectal cancer is a prime example of the multiple hit hypothesis, a cancer that is driven by the accumulation of sequential mutations in...