Showing posts with label mice. Show all posts
Showing posts with label mice. Show all posts
Thursday, January 23, 2025

Myoststin Knockout Improves Cachexia And Inhibits Tumor Growth

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Cachexia- induced muscle wasting is a problem in cancer. This paper tests the hypothesis that knocking out myostatin expression could help...
Thursday, November 21, 2024

Targeting Senescent Cells

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Here is a paper from several years ago suggesting that targeting senescent cells with programmed cell death can reverse aspects of aging i...
Thursday, June 20, 2024

Carbs And Protein For Muscle Recovery

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A paper from several years ago supports the traditional wisdom for post-workout muscle recover, abstract: The objective of the study w...
Thursday, September 15, 2022

Genome Editing In The (Mouse) Brain

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Here is a paper from several years ago discussing a fascinating and very promising finding.  We'll need to take a look at any subseque...
Thursday, July 14, 2022

Maternal Smoke Exposure And Cell Signaling

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It is know that maternal smoke exposure can possibly cause problems to the fetus.   Here is a mouse study demonstrating that offspring of ...
Thursday, May 19, 2022

Gene Editing For Muscular Dystrophy

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Here is a paper from several years ago discussing promising results with gene therapy in a mouse model of muscular dystrophy.  Abstract: ...
Thursday, October 21, 2021

Gene Therapy For Hearing Loss: Vector Development

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One major problem for gene therapy is designing a safe and effector vector for delivering the gene therapy material to the target cells.tis...
Monday, July 1, 2019

Lessons From Mice And Flies

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On Wnt signaling , abstract: Adult stem cells play critical roles in the basal maintenance of tissue integrity, also known as homeost...
Friday, February 15, 2019

More On Tumor Immune Evasion

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One mechanism of tumor immune evasion (at least in mice) is discussed here , abstract: Conventional type 1 dendritic cells (cDC1) are ...
Tuesday, November 20, 2018

Wild Mice And Microbiota

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Wild mice have different gut microbiota than lab mice and giving the lab mice the natural microbiota of the wild mice enhanced the health...
Thursday, November 15, 2018

PDGF Signaling And Obesity

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Here is a study suggesting that Platelet-derived growth factors and signaling related to that factors plays an important role in obesity b...
Wednesday, August 15, 2018

Wnt Signaling, DKK3, and Alzheimer's Disease Models

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More evidence of  dysfunctional Wnt signaling being involvedin the pathogenesis of Alzheimer’s disease (AD) is here , with the finding tha...
Wednesday, August 1, 2018

Down Syndrome and Alzheimer's

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Down syndrome patients accumulate brain features characteristic of Alzheimer's disease by age 40, and most go on to develop dementia.  ...
Friday, June 29, 2018

Genetic Structure Affected By Maternal Care (In Mice)

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Early life experiences, such as maternal care, alters the genetic structure in neurons in mice, with mobile genetic elements seemingly re...
Wednesday, June 13, 2018

Against Colitis And Cancer

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Chronic inflammation of the colon can increase risk for cancer; an antibody to a pro-inflammatory mediator can reduce inflammation in a mou...
Monday, June 11, 2018

Gene Expression After Death

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M ake of this what you will ; apparently, in mice and zebrafish, over one thousand genes show increased expression after the death of the...
Saturday, June 9, 2018

Fasting And Stem Cell Function

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In mice, a 24 hour fast improves the function of intestinal stem cells through effects on fatty acid oxidation (FAO).  Genetic knockout e...
Saturday, May 26, 2018

Notch And The Heart

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Notch signaling is required for proper heart function; abstract: Background -Nutrients are transported through endothelial cells before...
Tuesday, May 22, 2018

Three Is Enough

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Colorectal cancer is a prime example of the multiple hit hypothesis, a cancer that is driven by the accumulation of sequential mutations in...
Friday, May 4, 2018

Olanzapine Side Effects And Wnt Signaling

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Many drugs have unintended side effects.  A perfect example of this is weight gain and insulin resistance (metabolic syndrome characteris...