Showing posts with label immunotherapy. Show all posts
Showing posts with label immunotherapy. Show all posts
Friday, May 24, 2019

Sex Differences In Immune Checkpoint Therapy

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Women seem to do better than men in immune checkpoint therapy for cancer.  Studying such differences may help devise improved therapeutic a...
Friday, February 22, 2019

Protein Glycosylation Targeting Immunotherapy

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Another approach for anti-cancer immunotherapy, abstract: Protein glycosylation provides proteomic diversity in regulating protein loc...
Friday, February 15, 2019

More On Tumor Immune Evasion

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One mechanism of tumor immune evasion (at least in mice) is discussed here , abstract: Conventional type 1 dendritic cells (cDC1) are ...
Tuesday, December 18, 2018

Resistance to Cancer Immune Therapy: TNF Signaling

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Resistance to cancer immune therapy seems to involve downregulation of tumor necrosis factor (TNF) signaling, which possibly in the future ...
Friday, December 14, 2018

Genetic Variation And Immune Checkpoint Therapy

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Patient response to immune checkpoint therapy is influenced by patient genotype .  It may be necessary to determine individual genetic vari...
Sunday, September 23, 2018

Immune Checkpoint Inhibitor Therapy Biomarkers

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Immune checkpoints dampen the immune system’s ability to detect and fight cancer; thus, inhibits of such checkpoints, usually antibodies to...
Thursday, June 21, 2018

Cancer Immunotherapy: The Systemic Response

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An article  on cancer immunotherapy ; the abstract: Immune responses involve coordination across cell types and tissues. However, studi...
Wednesday, May 16, 2018

Ovarian Cancer Vaccine

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Personalized cancer vaccine for ovarian cancer; abstract: We conducted a pilot clinical trial testing a personalized vaccine generate...
Monday, May 7, 2018

Desmoplastic Melanoma And Immune Blockade

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Desmoplastic melanoma seems very responsive to immune blockade therapy; this is likely is due to the fact that these types of cancer have a...
Friday, March 30, 2018

Engineering Immunotherapy

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Engineering T cells to overcome tumor immune resistance- a possibly useful clinical strategy.  Abstract: Purpose Transforming growth ...
Sunday, March 25, 2018

One Potential Positive Of DNA Repair Deficiency In Cancer

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Usually, defects in DNA repair are viewed as a bad thing, leading to more of the type of mutations that can lead to cancer initiation and p...
Saturday, March 3, 2018

Expanding The Immunotherapy Arsenal

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A review on cancer immunotherapy is here , including the interesting approach of viruses that target and destroy tumor cells. Abstract: ...
Friday, March 2, 2018

Localized Immunotherapy

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Localized immunotherapy – injecting the agents directly into the tumor – has shown promise in studies.  Remarkably, if two tumors of the...
Tuesday, February 13, 2018

Monoclonal Antibodies For Severe Asthma

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By Adenosine - Own work, CC BY-SA 3.0, https://commons.wikimedia.org/w/index.php?curid=9659630 Monoclonal antibodies are being used ...
Monday, February 12, 2018

Chromatin Remodeling And Cancer Immunotherapy

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CC BY 3.0, https://en.wikipedia.org/w/index.php?curid=35818927 Immunotherapy against cancer is a promising treatment approach, but re...
Tuesday, January 16, 2018

Essential Genes And Cancer Immunotherapy

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Here is a paper looking at what genes may be essential for successful cancer immunotherapy. Abstract: Somatic gene mutations can alter...
Sunday, January 14, 2018

Myc Oncogene And Immune Detection Of Cancer

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Activation of the Myc oncogene in cancer helps produce immune-suppressed conditions that aids in the evasion of tumor immune surveillance. ...
Monday, January 8, 2018

A Double-Edged Sword: PDGF-DD

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The same factors secreted by tumors to make them grow and metastasize can also trigger immune reactions against them.  This finding can hel...
Wednesday, January 3, 2018

More On Neoantigens

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Neoantigens – aberrant proteins produced by mutated genes (e.g., in cancer) – are associated with long-term survivors of pancreatic cancer ...

Tumor Mutations and anti-PD-1 Immunotherapy Response

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Inhibitors of factors that themselves inhibit an anti-tumor response are promising therapeutic agents.  Here we see once again that respo...