Showing posts with label cancer therapy. Show all posts
Showing posts with label cancer therapy. Show all posts
Friday, May 24, 2019

Sex Differences In Immune Checkpoint Therapy

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Women seem to do better than men in immune checkpoint therapy for cancer.  Studying such differences may help devise improved therapeutic a...
Tuesday, March 26, 2019

Wnt Signaling And Angiogenesis

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Blocking angiogenesis to prevent tumors from getting their blood supply is an important therapeutic approach; Wnt signaling is involved .  ...
Friday, March 1, 2019

An Anti-Cancer Antibiotic

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An antibiotic, Nigericin, has anti-cancer activity, and one mechanism is through targeted suppression of Wnt signaling .  Abstract: Nig...
Tuesday, February 26, 2019

Wnt Inhibitor And Small Cell Lung Cancer

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A Wnt signaling inhibitor has some activity against small cell lung cancer.  Abstract: Small cell lung cancer (SCLC) is the most aggres...
Friday, February 22, 2019

Protein Glycosylation Targeting Immunotherapy

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Another approach for anti-cancer immunotherapy, abstract: Protein glycosylation provides proteomic diversity in regulating protein loc...
Monday, January 28, 2019

New Melanoma Therapy

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New therapeutic approach for melanoma described here .  Abstract: Development of an effective treatment against advanced tumors remains...
Tuesday, December 18, 2018

Resistance to Cancer Immune Therapy: TNF Signaling

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Resistance to cancer immune therapy seems to involve downregulation of tumor necrosis factor (TNF) signaling, which possibly in the future ...
Tuesday, November 27, 2018

The Circadian Clock And Cancer Therapy

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The circadian clock, that controls many cellular activities in a ‘timed” fashion, affects cancer and tumor development; hence targeting ...
Sunday, November 25, 2018

Targeting KRAS Mutations

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Targeting KRAS mutant cancers ; mutations of KRAS are frequent in many forms of cancer therefore this is an excellent therapeutic strategy....
Tuesday, November 20, 2018

Rimonabant And Colorectal Cancer

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Targeted killing of neoplastic colon cells; abstract: Colorectal cancer (CRC), like other tumor types, is a highly heterogeneous disea...
Wednesday, August 15, 2018

Protecting Normal Intestinal Cells From Chemotherapy: PUMA

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How to spare normal intestinal cells in chemotherapy. Interfering with the p53-PUMA axis by repressing PUMA can protect the normal cells ...
Monday, August 6, 2018

Endocrine Therapy And Breast Cancer Recurrence

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Endocrine therapy is typically used to prevent recurrent in breast cancer survivors, but it usually ended after five years because of side ...
Wednesday, July 25, 2018

Epigenetic Cancer Therapy

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Possible epigenetic-based cancer therapy for tumors with certain mutations; abstract: The lysine methyltransferase KMT2C (also known ...
Monday, May 28, 2018

Organoids In Cancer Research

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Tumor organoids are an increasingly useful research tool in our quest to understand cancer development and to develop anti-cancer therape...
Saturday, April 28, 2018

Chemotherapy Conundrum

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Chemotherapy is usually effective against cancer, but recurrence/resistance can occur.  Senescence – stopping of cell cycle and cell growth...
Tuesday, April 17, 2018

DNA Nanorobots Against Cancer

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DNA nanorobots against cancer. From article: DNA nanorobots are a somewhat new concept for drug delivery. They work by getting ...
Friday, March 30, 2018

Engineering Immunotherapy

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Engineering T cells to overcome tumor immune resistance- a possibly useful clinical strategy.  Abstract: Purpose Transforming growth ...
Sunday, March 18, 2018

HIF Repression Cancer Therapy

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Hypoxia – lack of oxygen – promotes the expression of  hypoxia-inducible factors that mediate cancer progression, including angiogenesis (...
Saturday, March 3, 2018

Expanding The Immunotherapy Arsenal

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A review on cancer immunotherapy is here , including the interesting approach of viruses that target and destroy tumor cells. Abstract: ...
Friday, March 2, 2018

Localized Immunotherapy

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Localized immunotherapy – injecting the agents directly into the tumor – has shown promise in studies.  Remarkably, if two tumors of the...